Longitudinal Evaluation of an N-Ethyl-N-Nitrosourea-Created Murine Model with Normal Pressure Hydrocephalus

Longitudinal Evaluation of an N-Ethyl-N-Nitrosourea-Created Murine Model with Normal Pressure Hydrocephalus

BACKGROUND Normal-pressure hydrocephalus (NPH) is a neurodegenerative disorder that usually occurs late in adult life. Clinically, the cardinal features include gait disturbances, urinary incontinence, and cognitive decline. METHODOLOGY/PRINCIPAL FINDINGS Herein we report the characterization of a novel mouse model of NPH (designated p23-ST1), created by N-ethyl-N-nitrosourea (ENU)-induced mu...

Induced by N-ethyl-N-nitrosourea

Phenotypic reversion of the rubber-band, muscledefective phenotype conferred by unc-93(e1500) was used to determine the utility of Nethyl-Nnitrosourea (ENU) as a mutagen for genetic research in Cuenmhabditis ekguns. In this system, ENU produces revertants at a frequency of 3 X equivalent to that of the commonly used mutagen, EMS. The gene identity of 154 ENU-induced revertants shows that the di...

Comment: the trouble with "n" in normal-pressure hydrocephalus.

Idiopathic normal-pressure hydrocephalus (iNPH) is a reversible syndrome of gait impairment, dementia, and incontinence that affects persons over 65 years of age.(1) Currently, the only effective treatment is surgical implantation of a shunt(2); however, the need for pharmacologic adjunctive treatments was noted at the 2005 NIH workshop on hydrocephalus.(3.)

N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.

In the mouse, random mutagenesis with N-ethyl-N-nitrosourea (ENU) has been used since the 1970s in forward mutagenesis screens. However, only in the last decade has ENU mutagenesis been harnessed to generate a myriad of new mouse mutations in large-scale genetic screens and focused, smaller efforts. The development of additional genetic tools, such as balancer chromosomes, refinements in geneti...

Teratogenic and Mutagenic Potential of Triethylenemelamine , Ethyl Methanesulfonate , / and N - Ethyl - N - Nitrosourea